microcrystalline cellulose msds fmc

4. Van Veen, G.K. Bolhuis, Y.S. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Are you sure you want to delete your template? Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Test Data Available. However, consumption of large quantities of the material may have a laxative effect. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. JFIF ` ` ZExif MM * J Q Q Q C If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. endobj . Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Fiber supplements can lessen the absorption of some . No. Browse Avicel PH-101 and related products at MilliporeSigma. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. These, in turn, are assembled into fibrils in the cell wall. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Learn about FMC's industry leading goal of net-zero emissions by 2035. *r_ *?~4$ &0Y# <> bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. MSDS Ref. Wu, K. Zuurman, H.W. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Chemical Formula: (C6H10O5)n 1.4. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. %PDF-1.3 CAS No. Microcrystalline Cellulose / Avicel PH-102. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. endobj Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Safety Data Sheet (SDS) Viewer. (1962). All rights reserved. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. By producing Avicel . Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge gac74 [#B6`Wnw7 TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. EMCOCEL XLM 90. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . 9,LL!z Terms and Conditions Compliance Solutions Industries About 3E News & Events . on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Avicel PC 611 Microcrystalline Cellulose. endobj The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Cellulose microcrystalline. These grades have particle sizes ranging from <30 to approximately 200. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe BIOACCUMULATIVE POTENTIAL <> cas:9032-51-3 msds CELLULOSE PAB. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Packaging: 34 x 50 kgs fiber drums. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. endobj METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. q86@on$^X_HuH;3` A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Validity Area. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. EMCOCEL 90 M. 130. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? endstream >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Thus, Avicel contributes no or very few calories to the food system. q9;v80 CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. The table below shows the most common physicochemical parameters of this raw material. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Avicel RC-591 & CL-611 - Description. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Watch Now. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Microcrystalline Cellulose Side Effects. A., and Smith, P. A. Avicel PC 611 (FMC Biopolymer) Supplied by. Molecular Weight null. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P endobj ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Molecular weight: Not Applicable 1.5. The cellulose molecule is formed through repeated condensation of cellobiose units. PDF (28.38 mb) 2022 Corporate Fact Sheet. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . >> : 1. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Gloves, eye protection and a dust mask should be used. In large quantities it provides dietary bulk and may lead to a laxative effect. . The data shown below apply only to Avicel PH 101. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Molecular weight: Not Applicable 1.5. 8 0 obj Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). % The short-term limit for total inhalable dust is 20 mg/m3. B;vLZpHU%ChUyD+[ \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Biologicals by FMC. endobj It is hygroscopic and insoluble in water. Trademarks: Avicel PH-102. CAS #: 9004-34-6 1.6. A family of polysaccharide products that allow distinctive drug delivery solutions. ( Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). An agricultural sciences company. <> INCI. /Type/Page MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Request media, explore upcoming events and read our latest updates. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Synergies to simplify formulation challenges and reduce operational costs. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Avicel Microcrystalline Cellulose Physical Properties. ( 1 0 obj {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. %PDF-1.4 << 6 0 obj They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. /Contents 4 0 R SDS - Safety Data Sheet. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Find answers in our support articles. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. ChemicalBook. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. }o]X4]. stream These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. EINECS #: 232-674-9 1.7. Safety Data Sheet for Cellulose microcrystalline 102331. PDF (4.11 mb) Footer menu 1. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. stream The most. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Looking for FMC'searnings news? The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline Cellulose NF. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. It works as a moisture sponge and permits the controlled growth of spheroids. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Explore how we work and why we apply science and creativity for a better world to everything we do. %PDF-1.4 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Manufactured by: China . Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. 5 0 obj We know that our customers need to provide reliable and consistent products to their patients. << Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Truly distinctive drug delivery solutions. No. : 9004-34-6 Date Approved: 01/31/2008 . 1.3. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ No. lH5JWy}DgKRR"Fs Go to Investor Relations. Microcrystalline Cellulose; Cellulose; Functions. All Rights Reserved. Some substance identifiers may have been claimed confidential, or may . };khd5x=fr >> Date Approved: 05/25/2010. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. <> It is also used in plaque assays for counting. 51395-75-6 Avicel RC 591. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Cellulose microcrystalline for column chromatography. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Battista, O. If you are already a ChemPoint customer then sign up for access to our online ordering website. CAS 9004-34-6, pH 5 - 7.5. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Doses up to 30 g per day appear to be . 130. Alginates also function as actives in some anti-reflux products. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. ( (&E. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Chemical Formula: (C6H10O5)n 1.4. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. . Production of Pharmaceutical Grade Microcrystalline Cellulose. Powder becomes slippery when wet. Superior Performance: Provides excellent water uptake and rapid swelling . Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. . MCC helps in the formation of spheres because of its . This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Hi, let us know if you have any questions as you visit our website. stream Have an order or account question? Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). MATERIAL SAFETY DATA SHEET. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . 3 0 obj ETHOCEL premium ethylcellulose resins are water-insoluble polymers. The typical mean particle size is 20200 m. MATERIAL SAFETY DATA SHEET. PDF (2.77 mb) 2021 FMC Sustainability Report. Quick Links. Learn about FMC's differentiated biologically-based crop solutions. stream : 160182 Date Approved: 05/25/2010 Revision No. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Home. No. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. /Parent 3 0 R 102331. 1.3. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine 4 0 obj Well-recognized product that can do it all. : 5. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. FMC, JRS and Mingtai were estimated to hold for . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. Are you looking for information about products and services by region? The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Microcrystalline Cellulose / Avicel PH-102. X\o^ msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Quantity: 1 700 kgs. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Catalog Number 102331. Delivering efficient and robust formulations. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . However, it yields non-digestible fibre. Millipore. % The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations.

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